Human Genome Project Using PCR Dissertation Example | Topics and Well Written Essays - 5000 words

Human Genome Project Using PCR - Dissertation Example Annexin A5 is a classical member of the chordate annexin family. It displays essential tetra structure and calcium-dependent phospholipid binding. It is one of the few annexins that can be found within the extracellular matrix. Annexin A5 has been postulated to be an inhibitor of coagulation due to its ability to attach to anionic phospholipids exposed of surfaces of platelets (Gerke & Moss, 2010). Consequently, this important gene inhibits platelet aggregation and down regulates surface presentation of tissue factor. The annexin A5 gene covers approximately 9 kb of the human chromosome 4q27. It comprises of one non-translated exon and 12 coding exons. Little is known about the regulation of the annexin A5 gene expression. Annexin A5 is an abundantly and ubiquitously expressed protein with highest concentrations in the liver, placenta and kidney. The human annexin A5 gene produces numerous transcripts and has a complex promoter which is subject to intricate regulation mechanism (Gerk e & Moss, 2010). Annexin A5 has been implicated in a wide range of disease phenotypes and etiology including recurrent pregnancy losses and cancer. It is a calcium and phospholipid protein localized within the surface of the placental syncytiotrophoblast layer. This protein performs vital anticoagulant function within the maternal blood and specifically at the intervillous space. Recently, it has been reported that polymorphisms in the promoter region of the annexin A5 gene can significantly be linked to recurrent pregnancy loss (RPL). Particularly, women who possess the M2 haplotype have more than two-fold higher risk of fetal loss compared to non-carriers (Bogdanova, Horst, Chlystun, Croucher, Nebel, Bohring, et al. 2010). Additionally, annexin A5 has been reported to be a vascular anticoagulant-?, placental anticoagulant protein I, liporcotin V, endonexin II, anchorin CII and placental protein 4. The annexin A5 gene spans 29 kilobases and has 13 exons which encode a single transcript of approximately 1.6 kb. The protein product of this gene has a molecular weight of approximately 35 kDa (Carcedo, Iglesias, Bances, Morgan & Fernandez, 2011). Official name of the gene: annexin A5 Official symbol: ANXA5 Gene type: protein coding Other names: PP4, ANX5, ENX2, RPRGL3 Chromosomal location: 4q27 (http://www.ncbi.nlm.nih.gov). Annexin A5 is a classical member of the chordate annexin family. It displays essential tetra structure and calcium-dependent phospholipid binding. It is one of the few annexins that can be found within the extracellular matrix. Annexin A5 has been postulated to be an inhibitor of coagulation due to its ability to attach to anionic phospholipids exposed

Reaching a Position of Chief Radiologic Technologist Assignment

Reaching a Position of Chief Radiologic Technologist - Assignment Example I plan to become a chief Radiologic Technologist by the next five years, that is, in 2018. For me to reach the set goal, there are interim goals I need to achieve to be well equipped and qualified for the position. I have listed these interim goals based on the order I need to achieve from the first to the last. First, is to introduce skill development program within my department. This will ensure that employees are well trained and have the ability and confidence to do their jobs effectively and efficiently. The other benefit of introducing the program is that the senior officers in my department will train me together with other employees on the skills that are appropriate to become an effective leader in Radiologic technology. This will give the skills and outlook of what shall be required of me when I get the position. The second interim goal is to complete my Bachelor Degree in Radiology technology by 2016. This is a requirement for one to take any managerial position within the Radiologic Technology. The third goal is to obtain a managerial position in Diagnostic Me dical Imaging department. I will be a manager in this department for two years after, which I will move to the next goal. The managerial position will assist me in assuming more role and responsibility in my department to prepare me for the Chief of Radiologist Technologist by the end of the year 2018. In doing this, it is my hope that I will be showing to the management my ability to assume higher roles in the department and the organization as a whole. Lastly, I will resume the chief executive position where I will remain until I create the next resolution. The resources needed to meet the set career goal vary accordingly, but some of the interim goals require the same resources. To begin with, the first interim goal, introduction of skill development program, requires thorough research into the type of the training and the equipment appropriate to achieve the skill development goals within the department and research into other departments of the radiologic technology and other organizations that have successfully implemented such training in their departments.